Summer 2017 Seminar Schedule






June 29 Carol Chrestensen, Kennesaw State University

"MAP kinase mediated regulation of endothelial Nitric Oxide Synthase (eNOS)"




Carol Chrestensen, Kennesaw State University,

There are few cellular signaling pathways as well-studied as the MAP kinase and nitric oxide (NO) generating pathways. Though much is known about these pathways, significant complexity remains to be untangled, especially as different cells and tissues respond differently to various stimuli. MAPK and NO-generating pathways are both critically important in a host of physiological (growth, differentiation, inflammation, apoptosis, vasodilation, immune function, and nerve transmission) and pathophysiological (diabetes, atherosclerosis, and cancer) processes. Understanding the intersection of eNOS and the three MAP kinases ERK, p38, and JNK is critically important to understanding normal physiology and disease processes. This presentation will focus on data highlighting the intersections between these pathways from both in vitro and cellular analyses and will discuss the physiological relevance of eNOS phosphorylation (pS602) by MAP kinases.